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在中國民間美術的藝術理念里， “圖必有意，意必吉祥”被視為不二法寶。而汗牛充棟的中國傳統(tǒng)吉祥瑞獸中，排名首位的，非龍莫屬，沒有之一。因此， “雙龍戲珠”這一意象在中國傳統(tǒng)文化中的重要地位自是不言而喻。

在中國古代神話中，龍珠是龍的精華，是它們修煉的原神所在，所以人們在藝術表達中，通過兩條龍對玉珠的爭奪，象征著人們對美好生活的追求。

雙龍戲珠是兩條龍或戲耍、或搶奪一顆火珠的表現形式。它的起源來自中國天文學中的星球運行圖，火珠是由月球演化來的。

從西漢開始，雙龍戲珠便成為一種吉祥喜慶的裝飾圖紋，多用于建筑彩畫和高貴豪華的器皿裝飾上。雙龍的形勢有左右相對、上下排列等多種樣式。但不管是何種排列，火珠均在中間，顯示出活潑生動的氣勢。

【雙龍戲珠是怎么玩的什么叫雙飛】
“雙龍戲珠”的吉祥圖案，其寓意包羅萬象——既預示著繁榮昌盛、國泰民安的景象；又包含了風調雨順、五谷豐登的希冀；還兼具平安長壽、飛黃騰達、吉祥如意的祈愿以及子孫延綿的生殖崇拜……象征著人們對美好生活的多元追求。

本期的封面故事，就帶大家賞析：“雙龍戲珠”入封面，為生物醫(yī)學領域帶來怎樣的吉祥？

A hydrogen peroxide activatable nanoprobe for light-controlled “double-check” multi-colour fluorescence imaging
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封面設計師：Arvin
學術支持：Auston
文章鏈接：
https://pubs.rsc.org/en/content/articlelanding/2020/nr/d0nr04881j/unauth#!divAbstract
摘要：
A new probe for precise and accurate bioimaging contributes significantly to advancing biomedical research for early disease diagnosis and treatment monitoring. Through wrapping a photochromic molecule (SP-Np-B) within a polymer nanoparticle, a new light-controlled multicolour fluorescence nanoprobe (Poly-SP-Np-B) is developed for precise fluorescence subcellular bioimaging. Poly-SP-Np-B shows an “OFF–ON” red-emitting fluorescence response upon alternate UV/Vis light irradiation. After activation by hydrogen peroxide (H2O2), a green-emitting Poly-SP-Npnanoparticle is generated, thus allowing light-controlled fluorescence response simultaneously, i.e., green and yellow switch upon alternate UV/Vis light irradiation for 10 and 20 s, respectively. Such a “blinking” fluorescence signal change is not possible by only using a photochromic molecule probe (SP-Np-B) with alternate UV/vis light irradiation for over 5 min. Poly-SP-Np-B has large isomerization kinetic constants (kSP–MR = 0.4543 s?1 and kMR–SP = 0.0809 s?1), excellent biocompatibility and lysosome distribution capability, enabling multicolour fluorescence imaging in live cells. With exo-/endogenous H2O2 activation in lysosomes, light-controlled “double-check” fluorescence imaging at the subcellular level is successfully achieved. More specifically, the change in fluorescence imaging is reversible in green, red and yellow channels in live cells upon excitation under alternate UV and visible light. This work thus provides a new strategy to develop switchable photochromic probes for precise fluorescence bioassay and bioimaging.